Half-Life (Normalesrd) Hours
1.5-4.1/3-7
Plasma Protein Binding %
45-60
Volume Of Distribution L/Kg
0.5-1.0
Dose For Normal Renal Function
12.5 mg/kg q6h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Ambrose PJ. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984; 9: 222-38. [PMID: 6375931] / Golper TA, Gleason JR, Vincent HH, et al. Drug removal during high efficiency and high flux hemodialysis. Contemp Iss Nephrol. 1993; 27: 175-208. [PMID unavailable] / Grafnetterová J, Vodrá zka Z, Jandová D, Schü ck O, Tomá sek R, Lachmanová J. The binding of chloramphenicol to serum proteins in patients with chronic renal insufficiency. Clin Nephrol. 1976; 6: 448-50. [PMID: 975643] / Keane WF, Everett ED, Golper TA, Gokal R, Halstenson C, Kawaguchi Y, et al. Peritoneal dialysis-related peritonitis treatment recommendations. 1993 update. The Ad Hoc Advisory Committee on Peritonitis Management. International Society for Peritoneal Dialysis. Perit Dial Int. 1993; 13: 14-28. [PMID: 8443273] / Slaughter RL, Cerra FB, Koup JR. Effect of hemodialysis on total body clearance of chloramphenicol. Am J Hosp Pharm. 1980; 37: 1083-6. [PMID: 7405936] / St Peter WL, Redic-Kill KA, Halstenson CE. Clinical pharmacokinetics of antibiotics in patients with impaired renal function. Clin Pharmacokinet. 1992; 22: 169-210. [PMID: 1559311]
Toxicity Notes
Reduce dose based on degree of renal impairment and plasma concentrations. Bone marrow suppression.