Half-Life (Normalesrd) Hours
1.7-2.9/6-8
Plasma Protein Binding %
45-60
Volume Of Distribution L/Kg
0.5-1.0
Dose For Normal Renal Function
500 mg-2 g q8-12h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50%[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25%[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 0.5 g after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 1000 mg q12h, [D]
References
Brogden RN, Heel RC. Aztreonam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1986; 31: 96-130. [PMID: 3512234] / Fillastre JP, Leroy A, Baudoin C, Humbert G, Swabb EA, Vertucci C, et al. Pharmaco-kinetics of aztreonam in patients with chronic renal failure. Clin Pharmacokinet. 1985; 10: 91-100. [PMID: 4038635] / Gerig JS, Bolton ND, Swabb EA, Scheld WM, Bolton WK. Effect of hemodialysis and peritoneal dialysis on aztreonam pharmacokinetics. Kidney Int. 1984; 26: 308-18. [PMID: 6542606] / Golper TA, Gleason JR, Vincent HH, et al. Drug removal during high efficiency and high flux hemodialysis. Contemp Iss Nephrol. 1993; 27: 175-208. [PMID unavailable] / Keane WF, Everett ED, Golper TA, Gokal R, Halstenson C, Kawaguchi Y, et al. Peritoneal dialysis-related peritonitis treatment recommendations. 1993 update. The Ad Hoc Advisory Committee on Peritonitis Management. International Society for Peritoneal Dialysis. Perit Dial Int. 1993; 13: 14-28. [PMID: 8443273] / St Peter WL, Redic-Kill KA, Halstenson CE. Clinical pharmacokinetics of antibiotics in patients with impaired renal function. Clin Pharmacokinet. 1992; 22: 169-210. [PMID: 1559311]