Half-Life (Normalesrd) Hours
9.8/No data
Plasma Protein Binding %
60-70
Volume Of Distribution L/Kg
2.9
Dose For Normal Renal Function
800 mg q24
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: No adjustment needed, unless clearance <30 mL/min, then 600 mg daily, [D]
References
Shi J, Montay G, Chapel S, Hardy P, Barrett JS, Sack M, et al. Pharmacokinetics and safety of the ketolide telithromycin in patients with renal impairment. J Clin Pharmacol. 2004; 44: 234-44. [PMID: 14973302]