Half-Life (Normalesrd) Hours
1.4/5-6
Plasma Protein Binding %
60-95
Volume Of Distribution L/Kg
0.6-1.2
Dose For Normal Renal Function
250-500 mg q6h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Golper TA, Marx MA. Drug dosing adjustments during continuous renal replacement therapies. Kidney Int Suppl. 1998; 66: S165-8. [PMID: 9573596] / Kanfer A, Stamatakis G, Torlotin JC, Fredj G, Kenouch S, Mé ry JP. Changes in erythromycin pharmacokinetics induced by renal failure. Clin Nephrol. 1987; 27: 147-50. [PMID: 3494560] / Kroboth PD, McNeil MA, Kreeger A, Dominguez J, Rault R. Hearing loss and erythromycin pharmacokinetics in a patient receiving hemodialysis. Arch Intern Med. 1983; 143: 1263-5. [PMID: 6860057]
Toxicity Notes
Rare ototoxicity with high doses in ESRD.