Half-Life (Normalesrd) Hours
30-44/No data
Plasma Protein Binding %
15-30
Volume Of Distribution L/Kg
>10
Dose For Normal Renal Function
500 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Ripley ED, Sica DA, Gehr TW, et al. Dirithryomycin pharmacokinetics in hemodialysis and chronic renal failure [Abstract]. Clin Pharmacol Ther. 1992; 51: 137. [PMID unavailable] / Sides GD, Cerimele BJ, Black HR, Busch U, DeSante KA. Pharmacokinetics of dirithromycin. J Antimicrob Chemother. 1993; 31 Suppl C: 65-75. [PMID: 8478313]