Excreted Unchanged %
20-30
Half-Life (Normalesrd) Hours
2.3-6.0/No data
Plasma Protein Binding %
70
Volume Of Distribution L/Kg
2-4
Dose For Normal Renal Function
250-500 mg q12h (Biaxin)
Second Dose
Second Dose: 1 g q24h (Biaxin XL)
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50-100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data : Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Chu SY, Sennello LT, Bunnell ST, Varga LL, Wilson DS, Sonders RC. Pharmaco-kinetics of clarithromycin, a new macrolide, after single ascending oral doses. Antimicrob Agents Chemother. 1992; 36: 2447-53. [PMID: 1489187] / Ferrero JL, Bopp BA, Marsh KC, Quigley SC, Johnson MJ, Anderson DJ, et al. Metabolism and disposition of clarithromycin in man. Drug Metab Dispos. 1990; 18: 441-6. [PMID: 1976065]