Excreted Unchanged %
85-95
Half-Life (Normalesrd) Hours
0.8-1.3/32
Plasma Protein Binding %
25
Volume Of Distribution L/Kg
0.3-0.4
Dose For Normal Renal Function
200-400 mg q12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q12h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q24h[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q3-5d[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Therasse DG, Farlow DS, Davidson RL, Quadracci LJ, Hatcher BL, Cerimele BJ, et al. Effects of renal dysfunction on the pharmacokinetics of loracarbef. Clin Pharmacol Ther. 1993; 54: 311-6. [PMID: 8375126]