Half-Life (Normalesrd) Hours
0.7-1.3/6-15
Plasma Protein Binding %
10
Volume Of Distribution L/Kg
0.25-0.46
Dose For Normal Renal Function
250 mg - 1 g q6-12h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50%[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Johnson CA, Welling PG, Zimmerman SW. Pharmacokinetics of oral cephradine in continuous ambulatory peritoneal dialysis patients. Nephron. 1984; 38: 57-61. [PMID: 6472532] / Searle M, Raman GV. Oral treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. Clin Nephrol. 1985; 23: 241-4. [PMID: 4006333] / Solomon AE, Briggs JD. The administration of cephradine to patients in renal failure. Br J Clin Pharmacol. 1975; 2: 443-8. [PMID: 786357]