Half-Life (Normalesrd) Hours
0.7/16
Plasma Protein Binding %
20
Volume Of Distribution L/Kg
0.35
Dose For Normal Renal Function
250-500 mg q6h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q6-8h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q8-12h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q12-24h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Bailey RR, Gower PE, Dash CH. The effect of impairment of renal function and haemodialysis on serum and urine levels of cephalexin. Postgrad Med J. 1970: Suppl: 60-4. [PMID: 5488211] / Bunke CM, Aronoff GR, Brier ME, Sloan RS, Luft FC. Cefazolin and cephalexin kinetics in continuous ambulatory peritoneal dialysis. Clin Pharmacol Ther. 1983; 33: 66-72. [PMID: 6848301] / Drew PJ, Casewell MW, Desai N, Houang ET, Simpson CN, Marsh FP. Cephalexin for the oral treatment of CAPD peritonitis. J Antimicrob Chemother. 1984; 13: 153-9. [PMID: 6368518]