Cefuroxime sodium

Excreted Unchanged %
90
Half-Life (Normalesrd) Hours
1.2/17
Plasma Protein Binding %
33
Volume Of Distribution L/Kg
0.13-1.8
Dose For Normal Renal Function
0.75-1.5 g q8h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q8h[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q8-12h[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24h[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 1 g q12h, [B]
References
Golper TA. Drug removal during continuous hemofiltration or hemodialysis. Contrib Nephrol. 1991; 93: 110-6. [PMID: 1802557] / Golper TA, Marx MA. Drug dosing adjustments during continuous renal replacement therapies. Kidney Int Suppl. 1998; 66: S165-8. [PMID: 9573596] / Weiss LG, Cars O, Danielson BG, Grahnen A, Wikstr&#246; m B. Pharmacokinetics of intravenous cefuroxime during intermittent and continuous arteriovenous hemofiltration. Clin Nephrol. 1988; 30: 282-6. [PMID: 3214972]