Half-Life (Normalesrd) Hours
1.2/17
Plasma Protein Binding %
35-50
Volume Of Distribution L/Kg
0.13-1.8
Dose For Normal Renal Function
250-500 mg q12h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Chan MK, Browning AK, Poole CJ, Matheson LA, Li CS, Baillod RA, et al. Cefuroxime pharmacokinetics in continuous and intermittent peritoneal dialysis. Nephron. 1985; 41: 161-5. [PMID: 4047273] / Walstad RA, Nilsen OG, Berg KJ. Pharmacokinetics and clinical effects of cefuroxime in patients with severe renal insufficiency. Eur J Clin Pharmacol. 1983; 24: 391-8. [PMID: 6861853]