Excreted Unchanged %
57-100
Half-Life (Normalesrd) Hours
1.4/35
Plasma Protein Binding %
28-50
Volume Of Distribution L/Kg
0.26-0.42
Dose For Normal Renal Function
1-2 g q8-12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q8-12h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12-24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24h[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 1 g after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 0.5-1 g/d
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Gross ML, Somani P, Ribner BS, Raeader R, Freimer EH, Higgins JT Jr. Ceftizoxime elimination kinetics in continuous ambulatory peritoneal dialysis. Clin Pharmacol Ther. 1983; 34: 673-80. [PMID: 6313276] / Kowalsky SF, Echols RM, Venezia AR, Andrews EA. Pharmacokinetics of ceftizoxime in subjects with various degrees of renal function. Antimicrob Agents Chemother. 1983; 24: 151-5. [PMID: 6314884]