Excreted Unchanged %
60-75
Half-Life (Normalesrd) Hours
1.5-2.7/22
Plasma Protein Binding %
70
Volume Of Distribution L/Kg
0.2
Dose For Normal Renal Function
400 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
25-50% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25-50% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 400 mg after dialysis only
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Barr WH, Lin CC, Radwanski E, Lim J, Symchowicz S, Affrime M. The pharmacokinetics of ceftibuten in humans. Diagn Microbiol Infect Dis. 1991; 14: 93-100. [PMID: 2013216] / Kelloway JS, Awni WM, Lin CC, Lim J, Affrime MB, Keane WF, et al. Pharmaco-kinetics of ceftibuten-cis and its trans metabolite in healthy volunteers and in patients with chronic renal insufficiency. Antimicrob Agents Chemother. 1991; 35: 2267-74. [PMID: 1803999]