Ceftazidime

Excreted Unchanged %
60-85
Half-Life (Normalesrd) Hours
1.2/13-25
Plasma Protein Binding %
5-24
Volume Of Distribution L/Kg
0.18-.31
Dose For Normal Renal Function
1-2 g q8h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q8-12h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12-24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24-48h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 1 g after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 0.5 g/d
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 1-2 g q12h or 2 g load followed by 3 g/d continuous infusion, [A]
References
Ackerman BH, Ross J, Tofte RW, Rotschafer JC. Effect of decreased renal function on the pharmacokinetics of ceftazidime. Antimicrob Agents Chemother. 1984; 25: 785-6. [PMID: 6378087] / Lin MS, Wang LS, Huang JD. Single- and multiple-dose pharmacokinetics of ceftazidime in infected patients with varying degrees of renal function. J Clin Pharmacol. 1989; 29: 331-7. [PMID: 2656776] / Mariat C, Venet C, Jehl F, Mwewa S, Lazarevic V, Diconne E, et al. Continuous infusion of ceftazidime in critically ill patients undergoing continuous venovenous haemodiafiltration: pharmacokinetic evaluation and dose recommendation. Crit Care. 2006; 10: R26. [PMID: 16507147] / Matzke GR, Frye RF, Joy MS, Palevsky PM. Determinants of ceftazidime clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis. Antimicrob Agents Chemother. 2000; 44: 1639-44. [PMID: 10817721] / Sato T, Okamoto K, Kitaura M, Kukita I, Kikuta K, Hamaguchi M. The pharmacokinetics of ceftazidime during hemodiafiltration in critically ill patients. Artif Organs. 1999; 23: 143-5. [PMID: 10027883] / Tourkantonis A, Nicolaidis P. Pharmacokinetics of ceftazidime in patients undergoing peritoneal dialysis. J Antimicrob Chemother. 1983; 12 Suppl A: 263-7. [PMID: 6352629] / Traunm&#252; ller F, Schenk P, Mittermeyer C, Thalhammer-Scherrer R, Ratheiser K, Thalhammer F. Clearance of ceftazidime during continuous venovenous haemofiltration in critically ill patients. J Antimicrob Chemother. 2002; 49: 129-34. [PMID: 11751776]