Excreted Unchanged %
35-45
Half-Life (Normalesrd) Hours
1.4/6
Plasma Protein Binding %
40
Volume Of Distribution L/Kg
0.23
Dose For Normal Renal Function
250-500 mg q12h
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% q12h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% q12h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% q12h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 250 mg after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Shyu WC, Pittman KA, Wilber RB, Matzke GR, Barbhaiya RH. Pharmacokinetics of cefprozil in healthy subjects and patients with renal impairment. J Clin Pharmacol. 1991; 31: 362-71. [PMID: 2037710]