Half-Life (Normalesrd) Hours
2.5/6-10
Plasma Protein Binding %
22-33
Volume Of Distribution L/Kg
0.6-1.2
Dose For Normal Renal Function
100-400 mg q12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q12h[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Borin MT, Hughes GS, Kelloway JS, Shapiro BE, Halstenson CE. Disposition of cefpodoxime proxetil in hemodialysis patients. J Clin Pharmacol. 1992; 32: 1038-44. [PMID: 1474165] / St Peter JV, Borin MT, Hughes GS, Kelloway JS, Shapiro BE, Halstenson CE. Disposition of cefpodoxime proxetil in healthy volunteers and patients with impaired renal function. Antimicrob Agents Chemother. 1992; 36: 126-31. [PMID: 1590677]