Half-Life (Normalesrd) Hours
3.5/13-25
Plasma Protein Binding %
85
Volume Of Distribution L/Kg
0.15
Dose For Normal Renal Function
1-2 g q12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
1-2 g q24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
1-2 g q48h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 1 g after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 1 g/d
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 1-2 g q24h, [D]
References
Browning MJ, Holt HA, White LO, Chapman ST, Banks RA, Reeves DS, et al. Pharmacokinetics of cefotetan in patients with end-stage renal failure on maintenance dialysis. J Antimicrob Chemother. 1986; 18: 103-6. [PMID: 3463556] / Ohkawa M, Hirano S, Tokunaga S, Motoi I, Shoda R, Ikeda A, et al. Pharmacokinetics of cefotetan in normal subjects and patients with impaired renal function. Antimicrob Agents Chemother. 1983; 23: 31-5. [PMID: 6572490] / Ward A, Richards DM. Cefotetan. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985; 30: 382-426. [PMID: 3905336]