Half-Life (Normalesrd) Hours
1/15
Plasma Protein Binding %
37
Volume Of Distribution L/Kg
0.15-0.55
Dose For Normal Renal Function
1-2 g q6-12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q6h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q6-12h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24h or dose [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 0.5-2 g after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 1 g/d
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 1 g q12h, [B]
References
Albin HC, Demotes-Mainard FM, Bouchet JL, Vincon GA, Martin-Dupont C. Pharmacokinetics of intravenous and intraperitoneal cefotaxime in chronic ambulatory peritoneal dialysis. Clin Pharmacol Ther. 1985; 38: 285-9. [PMID: 4028623] / Doluisio JT. Clinical pharmacokinetics of cefotaxime in patients with normal and reduced renal function. Rev Infect Dis. 1982; 4 Suppl: S333-45. [PMID: 6294782] / Golper TA. Drug removal during continuous hemofiltration or hemodialysis. Contrib Nephrol. 1991; 93: 110-6. [PMID: 1802557] / Golper TA, Marx MA. Drug dosing adjustments during continuous renal replacement therapies. Kidney Int Suppl. 1998; 66: S165-8. [PMID: 9573596] / Ings RM, Fillastre JP, Godin M, Leroy A, Humbert G. The pharmacokinetics of cefotaxime and its metabolites in subjects with normal and impaired renal function. Rev Infect Dis. 1982; 4 Suppl: S379-91. [PMID: 6294787] / Petersen J, Stewart RD, Catto GR, Edward N. Pharmacokinetics of intraperitoneal cefotaxime treatment of peritonitis in patients on continuous ambulatory peritoneal dialysis. Nephron. 1985; 40: 79-82. [PMID: 4000338] / Rodondi LC, Flaherty JF, Schoenfeld P, Barriere SL, Gambertoglio JG. Influence of coadministration on the pharmacokinetics of mezlocillin and cefotaxime in healthy volunteers and in patients with renal failure. Clin Pharmacol Ther. 1989; 45: 527-34. [PMID: 2721108] / Vos MC, Vincent HH, Yzerman EPF, et al. Drug clearance by continuous haemofiltration: results with the AN-69 capillary haemofilter and recommended dose adjustments for seven antibiotics. Drug Invest. 1994; 7: 315-22. [PMID unavailable]