Cefoperazone

Excreted Unchanged %
20
Half-Life (Normalesrd) Hours
1.6-2.5/2.9
Plasma Protein Binding %
90
Volume Of Distribution L/Kg
0.14-0.20
Dose For Normal Renal Function
1-2 g q12h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 1 g after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [C]
References
Golper TA. Drug removal during continuous hemofiltration or hemodialysis. Contrib Nephrol. 1991; 93: 110-6. [PMID: 1802557] / Golper TA, Marx MA. Drug dosing adjustments during continuous renal replacement therapies. Kidney Int Suppl. 1998; 66: S165-8. [PMID: 9573596] / Greenfield RA, Gerber AU, Craig WA. Pharmacokinetics of cefoperazone in patients with normal and impaired hepatic and renal function. Rev Infect Dis. 1983; 5 Suppl 1: S127-36. [PMID: 6221382] / Keller E, Jansen A, Pelz K, Hoppe-Seyler G, Schollmeyer P. Intraperitoneal and intravenous cefoperazone kinetics during continuous ambulatory peritoneal dialysis. Clin Pharmacol Ther. 1984; 35: 208-13. [PMID: 6692648] / Spyker DA, Richmond JD, Scheld WM, Bolton WK. Pharmacokinetics of multiple-dose cefoperazone in hemodialysis patients. Am J Nephrol. 1985; 5: 355-60. [PMID: 4061504] / Trollfors B, Ahlm&#233; n J, Alestig K. Renal function during cefoperazone treatment. J Antimicrob Chemother. 1982; 9: 485-7. [PMID: 6213595]