Half-Life (Normalesrd) Hours
2.2/18
Plasma Protein Binding %
16
Volume Of Distribution L/Kg
0.3
Dose For Normal Renal Function
250-2000 mg q8-12h
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50-100% q24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25-50% q24h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 1-2 g q12h, [A]
References
Allaouchiche B, Breilh D, Jaumain H, Gaillard B, Renard S, Saux MC. Pharmaco-kinetics of cefepime during continuous venovenous hemodiafiltration. Antimicrob Agents Chemother. 1997; 41: 2424-7. [PMID: 9371344] / Barbhaiya RH, Knupp CA, Forgue ST, Matzke GR, Guay DR, Pittman KA. Pharmacokinetics of cefepime in subjects with renal insufficiency. Clin Pharmacol Ther. 1990; 48: 268-76. [PMID: 2401125] / Barbhaiya RH, Forgue ST, Gleason CR, Knupp CA, Pittman KA, Weidler DJ, et al. Pharmacokinetics of cefepime after single and multiple intravenous administrations in healthy subjects. Antimicrob Agents Chemother. 1992; 36: 552-7. [PMID: 1622165] / Barbhaiya RH, Knupp CA, Pfeffer M, Zaccardelli D, Dukes GM, Mattern W, et al. Pharmacokinetics of cefepime in patients undergoing continuous ambulatory peritoneal dialysis. Antimicrob Agents Chemother. 1992; 36: 1387-91. [PMID: 1510432] / Malone RS, Fish DN, Abraham E, Teitelbaum I. Pharmacokinetics of cefepime during continuous renal replacement therapy in critically ill patients. Antimicrob Agents Chemother. 2001; 45: 3148-55. [PMID: 11600370]