Half-Life (Normalesrd) Hours
0.8-1.6/2.7-4.7
Plasma Protein Binding %
88
Volume Of Distribution L/Kg
0.1
Dose For Normal Renal Function
200-400 mg q12h
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
200 mg bid (qd for CrCl <30 mL/min) [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
200 mg qd [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
Toxicity Notes
Drug reduces plasma carnitine levels. Patients with reduced muscle mass and patients with renal failure may be at increased risk. HD (4 hr) removed 30% of dose but did not change elimination half-life.