Excreted Unchanged %
12-31
Half-Life (Normalesrd) Hours
1.7/4-21
Plasma Protein Binding %
60-73
Volume Of Distribution L/Kg
1.6-2.1
Dose For Normal Renal Function
300 mg q12h or600 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
300 mg q24h for CrCl <30 mL/min [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
300 mg q48h[B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Hishida A, Ohishi K, Nagashima S, Kanamaru M, Obara M, Kitada A. Pharmacokinetic study of an oral cephalosporin, cefdinir, in hemodialysis patients. Antimicrob Agents Chemother. 1998; 42: 1718-21. [PMID: 9661010] / Tomino Y, Fukui M, Hamada C, Inoue S, Osada S. Pharmacokinetics of cefdinir and its transfer to dialysate in patients with chronic renal failure undergoing continuous ambulatory peritoneal dialysis. Arzneimittelforschung. 1998; 48: 862-7. [PMID: 9748717]
Toxicity Notes
HD clearance (4 hr) is 76 mL/min with 61% fractional removal of drug. PD removal is minimal.