Excreted Unchanged %
75-95
Half-Life (Normalesrd) Hours
2/40-70
Plasma Protein Binding %
80
Volume Of Distribution L/Kg
0.13-0.22
Dose For Normal Renal Function
0.25-2 g q6h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% q8h[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% q12h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% q24-48h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 15-20 mg/kg after dialysis, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: 0.5 g q12h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Brogard JM, Pinget M, Brandt C, Lavillaureix J. Pharmacokinetics of cefazolin in patients with renal failure; special reference to hemodialysis. J Clin Pharmacol. 1977; 17: 225-30. [PMID: 849996] / Fogel MA, Nussbaum PB, Feintzeig ID, Hunt WA, Gavin JP, Kim RC. Cefazolin in chronic hemodialysis patients: a safe, effective alternative to vancomycin. Am J Kidney Dis. 1998; 32: 401-9. [PMID: 9740155] / Kaye D, Wenger N, Agarwal B. Pharmacology of intraperitoneal cefazolin in patients undergoing peritoneal dialysis. Antimicrob Agents Chemother. 1978; 14: 318-21. [PMID: 708010] / Marx MA, Frye RF, Matzke GR, Golper TA. Cefazolin as empiric therapy in hemodialysis-related infections: efficacy and blood concentrations. Am J Kidney Dis. 1998; 32: 410-4. [PMID: 9740156] / Sowinski KM, Mueller BA, Grabe DW, Manley HJ, Frye RF, Bailie GR, et al. Cefazolin dialytic clearance by high-efficiency and high-flux hemodialyzers. Am J Kidney Dis. 2001; 37: 766-76. [PMID: 11273877]