Excreted Unchanged %
50-100
Half-Life (Normalesrd) Hours
1/6-11
Plasma Protein Binding %
75
Volume Of Distribution L/Kg
0.16-0.25
Dose For Normal Renal Function
0.5-1 g q4-8h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q6h[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q6-8h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q8-12h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 0.5-1 g after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 0.5-1 g q12h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Czerwinski AW, Pederson JA. Pharmacokinetics of cefamandole in patients with renal impairment. Antimicrob Agents Chemother. 1979; 15: 161-4. [PMID: 426510] / Gambertoglio JG, Aziz NS, Lin ET, Grausz H, Naughton JL, Benet LZ. Cefa-mandole kinetics in uremic patients undergoing hemodialysis. Clin Pharmacol Ther. 1979; 26: 592-9. [PMID: 498702] / Pancorbo S, Comty C. Pharmacokinetics of cefamandole in patients undergoing continuous ambulatory peritoneal dialysis. Perit Dial Bull. 1983; 2: 135-7. [PMID unavailable]