Excreted Unchanged %
70-90
Half-Life (Normalesrd) Hours
1.4/22
Plasma Protein Binding %
20
Volume Of Distribution L/Kg
0.31
Dose For Normal Renal Function
0.5-1 g q12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q12h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12-24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q36h[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 0.5-1 g after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 0.5 g/d
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Cutler RE, Blair AD, Kelly MR. Cefadroxil kinetics in patients with renal insufficiency. Clin Pharmacol Ther. 1979; 25: 514-21. [PMID: 436355] / Leroy A, Humbert G, Godin M, Fillastre JP. Pharmacokinetics of cefadroxil in patients with impaired renal function. J Antimicrob Chemother. 1982; 10 Suppl B: 39-46. [PMID: 7142092]