Half-Life (Normalesrd) Hours
1/3
Plasma Protein Binding %
25
Volume Of Distribution L/Kg
0.24-0.35
Dose For Normal Renal Function
250-500 mg q8h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 250-500 mg after dialysis, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: 250-500 mg q8h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Spyker DA, Gober LL, Scheld WM, Sande MA, Bolton WK. Pharmacokinetics of cefaclor in renal failure: effects of multiple doses and hemodialysis. Antimicrob Agents Chemother. 1982; 21: 278-81. [PMID: 7073265]