General Toxicity Notes
Nephrotoxic, ototoxic. Toxicity worse when hyperbilirubinemic. Measure serum levels for efficacy and toxicity. Peritoneal absorption increases with presence of inflammation. Vd increases with edema, obesity, and ascites. Do not use once-daily dosing in patients with CrCl <30-40 mL/min or in patients with acute renal failure or uncertain level of kidney function.
Half-Life (Normalesrd) Hours
2.5/100
Plasma Protein Binding %
35
Volume Of Distribution L/Kg
0.26
Dose For Normal Renal Function
1-2 g q6-12h(1.0 g q24h for tuberculosis)
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q24h[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q24-72h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q72-96h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: normal dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 20-40 mg/L/d
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, monitor levels, [D]
Toxicity Notes
May be less nephrotoxic but more ototoxic than other members of class.