General Toxicity Notes
Nephrotoxic, ototoxic. Toxicity worse when hyperbilirubinemic. Measure serum levels for efficacy and toxicity. Peritoneal absorption increases with presence of inflammation. Vd increases with edema, obesity, and ascites. Do not use once-daily dosing in patients with CrCl <30-40 mL/min or in patients with acute renal failure or uncertain level of kidney function.
Excreted Unchanged %
50-90
Half-Life (Normalesrd) Hours
1.8-5.0/40-96
Plasma Protein Binding %
<5
Volume Of Distribution L/Kg
0.19-0.23
Dose For Normal Renal Function
7.5 mg/kg q12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% q12-24h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% q24-72h by levels [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% q48-72h by levels [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: full dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 15-20 mg/L/d
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, monitor levels, [D]