Half-Life (Normalesrd) Hours
2-4 min/Unchanged
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
2-3
Dose For Normal Renal Function
Many routes and methods
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate, [D]
References
Fung HL. Pharmacokinetics and pharmacodynamics of organic nitrates. Am J Cardiol. 1987; 60: 4H-9H. [PMID: 3120565] / Todd PA, Goa KL, Langtry HD. Transdermal nitroglycerin (glyceryl trinitrate). A review of its pharmacology and therapeutic use. Drugs. 1990; 40: 880-902. [PMID: 2127741]