Half-Life (Normalesrd) Hours
0.6-2.0/Unchanged
Plasma Protein Binding %
28
Volume Of Distribution L/Kg
2.2-8.6
Dose For Normal Renal Function
2.5-5 mg 15 min before activity
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Evers J, Bonn R, Boertz A, Cawello W, Dickmans HA, Weiss M. Pharmacokinetics of isosorbide dinitrate, isosorbide-2-nitrate and isosorbide-5-nitrate in renal insufficiency after repeated oral dosage. Klin Wochenschr. 1989; 67: 342-8. [PMID: 2709744] / Fung HL. Pharmacokinetics and pharmacodynamics of organic nitrates. Am J Cardiol. 1987; 60: 4H-9H. [PMID: 3120565]
Toxicity Notes
Every dosing regimen for ISDN must provide a daily dose-free interval to minimize the development of tolerance. In the case of sublingual tablets, it is probably true that one of the daily dose-free intervals must be somewhat longer than 14 hours.