Excreted Unchanged %
Unknown
Half-Life (Normalesrd) Hours
24/No data
Plasma Protein Binding %
Unknown
Volume Of Distribution L/Kg
Unknown
Dose For Normal Renal Function
10 mg q12h
Second Dose
Second Dose: 20-40 mg q8-12h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
1 mg tid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Seyffart G. Drug Dosage in Renal Insufficiency. Dordrecht, The Netherlands: Kluwer Academic; 1991.
Toxicity Notes
The half-life of orally administered phenoxybenzamine is not known; however, the half-life of the IV-administered drug is approximately 24 hours. Avoid in patients with renal insufficiency.