Excreted Unchanged %
75-80
Half-Life (Normalesrd) Hours
0.5/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
No data
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
5-10 mg q8h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
5-10 mg q8h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
No data[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 5 mg q8h
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate, [D]
References
McTavish D, Goa KL. Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders. Drugs. 1989; 38: 757-77. [PMID: 2480881]
Toxicity Notes
Increased blood pressure.