Excreted Unchanged %
10-40
Half-Life (Normalesrd) Hours
2.6-8.3/No data
Plasma Protein Binding %
20-40
Volume Of Distribution L/Kg
1.3-1.6
Dose For Normal Renal Function
5-10 µg/kg/min
Second Dose
Second Dose: daily dose <10 mg/kg
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50-75% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No dat
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [B]
References
Bottorff MB, Rutledge DR, Pieper JA. Evaluation of intravenous amrinone: the first of a new class of positive inotropic agents with vasodilator properties. Pharmacotherapy. 1985; 5: 227-37. [PMID: 3906583] / Lawless S, Restaino I, Azin S, Corddry D. Effect of continuous arteriovenous haemo-filtration on pharmacokinetics of amrinone. Clin Pharmacokinet. 1993; 25: 80-2. [PMID: 8354019]
Toxicity Notes
Thrombocytopenia. Nausea, vomiting in ESRD.