Thiazides

General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Excreted Unchanged %
>95
Half-Life (Normalesrd) Hours
6-8/12-20
Plasma Protein Binding %
40
Volume Of Distribution L/Kg
3.0
Dose For Normal Renal Function
25-50 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicabl
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Niemeyer C, Hasenfuss G, Wais U, Knauf H, Sch&#246; fer-Korting M, Mutschler E. Pharmacokinetics of hydrochlorothiazide in relation to renal function. Eur J Clin Pharmacol. 1983; 24: 661-5. [PMID: 6873147]
Toxicity Notes
Usually ineffective when GFR <30 mL/min. Effective at low GFR in combination with loop diuretic. Hyperuricemia.