General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Excreted Unchanged %
20-30
Half-Life (Normalesrd) Hours
10-35/Unchanged
Plasma Protein Binding %
98
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
25 mg tid-qid
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q6-12h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12-24h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicabl
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Avoid, [D]
References
Morris RG, Frewin DB, Taylor WB, Glistak ML, Lehmann DR. The effect of renal and hepatic impairment and of spironolactone on digoxin immunoassays. Eur J Clin Pharmacol. 1988; 34: 233-9. [PMID: 3396618] / Skluth HA, Gums JG. Spironolactone: a re-examination. DICP. 1990; 24: 52-9. [PMID: 2405587]
Toxicity Notes
Active metabolites with long half-life. Hyperkalemia common when GFR <30 mL/min, especially in diabetics. Gynecomastia, hyperchloremic acidosis. Increases serum by immunoassay interference.