General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Half-Life (Normalesrd) Hours
26/No data
Plasma Protein Binding %
84
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
1-4 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Ineffective [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Ineffective, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Ineffective, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Seyffart G. Drug Dosage in Renal Insufficiency. Dordrecht, The Netherlands: Kluwer Academic; 1991.
Toxicity Notes
Usually ineffective when GFR <30 mL/min.