General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Half-Life (Normalesrd) Hours
4-20/No data
Plasma Protein Binding %
95
Volume Of Distribution L/Kg
1.6
Dose For Normal Renal Function
5-20mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Tilstone WJ, Dargie H, Dargie EN, Morgan HG, Kennedy AC. Pharmacokinetics of metolazone in normal subjects and in patients with cardiac or renal failure. Clin Pharmacol Ther. 1974; 16: 322-9. [PMID: 4853601]
Toxicity Notes
High doses effective in ESRD. Gynecomastia, impotence.