Hydroflumethiazide

General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Excreted Unchanged %
55-65
Half-Life (Normalesrd) Hours
17/ No data
Plasma Protein Binding %
75
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
25-200 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Ineffective [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicabl
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Br&#248; rs O. Pharmacokinetics of hydroflumethiazide during repeated administration in congestive heart failure. Acta Pharmacol Toxicol (Copenh). 1982; 51: 177-81. [PMID: 7136723] / Br&#248; rs O, Jacobsen S. Distribution of elimination of hydroflumethiazide in man. Eur J Clin Pharmacol. 1979; 16: 125-31. [PMID: 499309] / Yakatan GJ, Smith RB, Frome EL, Doluisio JT. Pharmacokinetics of orally administered hydroflumethiazide in man. J Clin Pharmacol. 1977; 17: 37-47. [PMID: 833338]
Toxicity Notes
Usually ineffective with GFR <30 mL/min. Effective at low GFR in combination with loop diuretic.