General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Half-Life (Normalesrd) Hours
<5.6-14.8/No data
Plasma Protein Binding %
65
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
6.25-200 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Ineffective [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Seyffart G. Drug Dosage in Renal Insufficiency. Dordrecht, The Netherlands: Kluwer Academic; 1991.
Toxicity Notes
Usually ineffective with GFR <30 mL/min. Effective at low GFR in combination with loop diuretic.