General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Excreted Unchanged %
50-80
Half-Life (Normalesrd) Hours
0.5-2.1/2-4
Plasma Protein Binding %
95
Volume Of Distribution L/Kg
0.07-0.2
Dose For Normal Renal Function
20-300 mg q12-24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [A]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Ponto LL, Schoenwald RD. Furosemide (frusemide). A pharmacokinetic/pharmaco-dynamic review (Part I). Clin Pharmacokinet. 1990; 18: 381-408. [PMID: 2185908] / Traeger A, Stein G, Sperschneider H, Keil E. Pharmacokinetic and pharmacodynamic effects of furosemide in patients with impaired renal function. Int J Clin Pharmacol Ther Toxicol. 1984; 22: 481-6. [PMID: 6500766]
Toxicity Notes
Ototoxicity increased in ESRD, especially in combination with aminoglycosides. High doses effective in ESRD.