General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Half-Life (Normalesrd) Hours
2-4/No data
Plasma Protein Binding %
90
Volume Of Distribution L/Kg
0.1
Dose For Normal Renal Function
50-100 mg tid
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q8-12h [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q8-12h [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Pillay VK, Schwartz FD, Aimi K, Kark RM. Transient and permanent deafness following treatment with ethacrynic acid in renal failure. Lancet. 1969; 1: 77-9. [PMID: 4178003]
Toxicity Notes
Ototoxicity increased in ESRD in combination with aminoglycosides.