General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Half-Life (Normalesrd) Hours
44-80/Unknown
Plasma Protein Binding %
76-90
Volume Of Distribution L/Kg
3.9
Dose For Normal Renal Function
25 mg q24h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q24h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q24h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicabl
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Mulley BA, Parr GD, Rye RM. Pharmacokinetics of chlorthalidone. Dependence of biological half life on blood carbonic anhydrase levels. Eur J Clin Pharmacol. 1980; 17: 203-7. [PMID: 6767611]
Toxicity Notes
Ineffective with low GFR.