General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Half-Life (Normalesrd) Hours
0.75-2/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
500-1,000 mg q12-24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Ineffective [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, et al. Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin. J Clin Pharmacol. 1982; 22: 32-41. [PMID: 7061724]
Toxicity Notes
Usually ineffective with GFR <30 mL/min. Effective at low GFR in combination with loop diuretic.