General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Half-Life (Normalesrd) Hours
6-21/10-144
Plasma Protein Binding %
30-40
Volume Of Distribution L/Kg
5.0-5.2
Dose For Normal Renal Function
5.0 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
George CF. Amiloride handling in renal failure. Br J Clin Pharmacol. 1980; 9: 94-5. [PMID: 7356897] / Spahn H, Reuter K, Mutschler E, Gerok W, Knauf H. Pharmacokinetics of amiloride in renal and hepatic disease. Eur J Clin Pharmacol. 1987; 33: 493-8. [PMID: 3428342]
Toxicity Notes
Hyperkalemia with GFR <30 mL/min, especially in diabetics. Hyperchloremic metabolic acidosis.