General Toxicity Notes
Natriuretic drugs may cause extracellular fluid volume depletion.
Half-Life (Normalesrd) Hours
1.7-5.8/No data
Plasma Protein Binding %
70-90
Volume Of Distribution L/Kg
0.2
Dose For Normal Renal Function
250 mg q6-12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q6h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No dat
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Chapron DJ, Gomolin IH, Sweeney KR. Acetazolamide blood concentrations are excessive in the elderly: propensity for acidosis and relationship to renal function. J Clin Pharmacol. 1989; 29: 348-53. [PMID: 2498399] / Roy LF, Dufresne LR, Legault L, Long H, Morin C. Acetazolamide in hemodialysis patients: a rational use after ocular surgery. Am J Kidney Dis. 1992; 20: 650-2. [PMID: 1462998] / Schwenk MH, St Peter WL, Meese MG, Singhal PC. Acetazolamide toxicity and pharmacokinetics in patients receiving hemodialysis. Pharmacotherapy. 1995; 15: 522-7. [PMID: 7479208]
Toxicity Notes
May potentiate acidosis. Ineffective as diuretic in ESRD. May cause neurologic side effects in dialysis patients.