General Toxicity Notes
Add to uremic gastrointestinal symptoms. Toxicity enhanced by hypokalemia and hypomagnesemia during dialysis.
Excreted Unchanged %
40-50
Half-Life (Normalesrd) Hours
21/60-70
Plasma Protein Binding %
40
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
0.25 mg load, then 0.1 mg q12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q12-24h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q24-36h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q36-48h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Ochs HR, Greenblatt DJ, Bodem G, Dengler HJ. Disease-related alterations in cardiac glycoside disposition. Clin Pharmacokinet. 1982; 7: 434-51. [PMID: 6754209]