General Toxicity Notes
Headache, edema, flushing, dizziness.
Half-Life (Normalesrd) Hours
6.6-7.9/6.8-9.7
Plasma Protein Binding %
99
Volume Of Distribution L/Kg
2.3-7.1
Dose For Normal Renal Function
10 mg q24h
Second Dose
Second Dose: 10-40 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [A]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Boelaert J, Valcke Y, Dammekens H, De Vriese G, Ahr G, Schurgers M, et al. Pharmacokinetics of nisoldipine in renal dysfunction. Eur J Clin Pharmacol. 1988; 34: 207-9. [PMID: 3383992] / Mitchell J, Frishman W, Heiman M. Nisoldipine: a new dihydropyridine calcium-channel blocker. J Clin Pharmacol. 1993; 33: 46-52. [PMID: 8429113] / Shionoiri H, Minamisawa K, Masumori S, Satta H, Minamisawa M, Takizawa T, et al. Pharmacokinetics and pharmacodynamics of nisoldipine in hypertensive patients with normal and mild to moderate impaired renal function. Arzneimittelforschung. 1995; 45: 785-9. [PMID: 8573223]
Toxicity Notes
May increase digoxin levels.