General Toxicity Notes
Headache, edema, flushing, dizziness.
Half-Life (Normalesrd) Hours
1.0-2.8/22
Plasma Protein Binding %
98
Volume Of Distribution L/Kg
0.9-2.3
Dose For Normal Renal Function
30 mg q8h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Langley MS, Sorkin EM. Nimodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cerebrovascular disease. Drugs. 1989; 37: 669-99. [PMID: 2663415]
Toxicity Notes
May lower blood pressure.