General Toxicity Notes
Headache, edema, flushing, dizziness.
Half-Life (Normalesrd) Hours
1.3-5/5-7
Plasma Protein Binding %
98-99
Volume Of Distribution L/Kg
0.8-1.4
Dose For Normal Renal Function
20-40 mg PO tid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Ahmed JH, Grant AC, Rodger RS, Murray GR, Elliott HL. Inhibitory effect of uraemia on the hepatic clearance and metabolism of nicardipine. Br J Clin Pharmacol. 1991; 32: 57-62. [PMID: 1888642] / Sorkin EM, Clissold SP. Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders. Drugs. 1987; 33: 296-345. [PMID: 3297616]
Toxicity Notes
Uremia inhibits hepatic metabolism of nicardipine. Patients with renal failure may respond at lower doses or accumulate drug. May increase digoxin levels. For IV use, initiate at 5 mg/hr; increase by 2.5 mg/hr every 15 minutes up to a maximum of 15 mg/hr.