Felodipine

General Toxicity Notes
Headache, edema, flushing, dizziness.
Excreted Unchanged %
<1
Half-Life (Normalesrd) Hours
10-14/21-24
Plasma Protein Binding %
99
Volume Of Distribution L/Kg
9-10
Dose For Normal Renal Function
5 mg q24h
Second Dose
Second Dose: 2.5-10 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Blychert E. Felodipine pharmacokinetics and plasma concentration vs effect relationships. Blood Press Suppl. 1992; 2: 1-30. [PMID: 1343111] / Blychert E, Edgar B, Elmfeldt D, Hedner T. A population study of the pharmacokinetics of felodipine. Br J Clin Pharmacol. 1991; 31: 15-24. [PMID: 2015166] / Buur T, Larsson R, Reg&#229; rdh CG, Aberg J. Pharmacokinetics of felodipine in chronic hemodialysis patients. J Clin Pharmacol. 1991; 31: 709-13. [PMID: 1880229] / Todd PA, Faulds D. Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders. Drugs. 1992; 44: 251-77.[PMID: 1382018] / Videbaek LM, Jacobsen IA. Crossover comparison of the pharmacokinetics of amlodipine and felodipine ER in hypertensive patients. Int J Clin Pharmacol Ther. 1997; 35: 514-8. [PMID: 9401833]
Toxicity Notes
May increase digoxin levels.